The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1.

doi:10.1016/j.celrep.2021.109864

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Article

The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1.

Cell reports - 19 Oct 2021

Walter Jonas, Bolognin Silvia, Poovathingal Suresh K, Magni Stefano, Gérard Deborah, Antony Paul M A, Nickels Sarah L, Salamanca Luis, Berger Emanuel, Smits Lisa M, Grzyb Kamil, Perfeito Rita, Hoel Fredrik, Qing Xiaobing, Ohnmacht Jochen, Bertacchi Michele, Jarazo Javier, Ignac Tomasz, Monzel Anna S, Gonzalez-Cano Laura, Krüger Rejko, Sauter Thomas, Studer Michèle, de Almeida Luis Pereira, Tronstad Karl J, Sinkkonen Lasse, Skupin Alexander, Schwamborn Jens C

Abstract excerpt

Increasing evidence suggests that neurodevelopmental alterations might contribute to increase the susceptibility to develop neurodegenerative diseases. We investigate the occurrence of developmental abnormalities in dopaminergic neurons in a model of Parkinson's disease (PD). We monitor the differentiation of human patient-specific neuroepithelial stem cells (NESCs) into dopaminergic neurons. Using...

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PMID: 34686322
DOI: 10.1016/j.celrep.2021.109864

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