Article
On the road to leucine-rich repeat kinase 2 signalling: evidence from cellular and in vivo studies.
Neuro-Signals - 1 Jan 2011
Daniëls V, Baekelandt V, Taymans J-M
Abstract excerpt
Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Although PD has long been considered a purely sporadic disorder, genetic research has revealed an underlying genetic cause in at least 10% of all PD cases. To date, mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of familial PD. Moreover, given the strong clinical and neuropathological...
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