Article

Single-cell transcriptomic changes in oligodendroglial lineage cells derived from Parkinson’s disease patient-iPSCs with LRRK2-G2019S mutation

2024-07-03

Abstract excerpt

Despite extensive research, the contribution of the LRRK2 p.G2019S mutation to Parkinson’s disease (PD) remains unclear. Recent findings indicate oligodendrocytes (ODCs) and their progenitors are vulnerable in PD pathogenesis. Notably, oligodendrocyte precursor cells (OPCs) exhibit high endogenous expression of LRRK2 . We induced PD patient-iPSCs with the LRRK2 p.G2019S mutation into oligodendroglial lineages and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 63c715ea-5eed-5ac9-b78e-7aa75d2bcc57
DOI: 10.1101/2024.07.01.601392

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell transcriptomic changes in oligodendroglial lineage cells derived from Parkinson’s disease patient-iPSCs with LRRK2-G2019S mutationDOI 10.1101/2024.07.01.601392Read

Oligodendrocyte subtype diversity underlines clinical progression in Parkinson’s diseaseSemantic proximity Read

PARKINSON’S DISEASE-ASSOCIATED <i>PINK1</i> LOSS DISRUPTS ENSHEATHING GLIA AND CAUSES DOPAMINERGIC NEURON SYNAPSE LOSSSemantic proximity Read

Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression.Semantic proximity Read

Single-Cell Transcriptomic Analysis Reveals Molecular Diversity of Human Oligodendrocyte Progenitor CellsSemantic proximity Read

Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells.Semantic proximity Read

Transcriptomic changes in oligodendrocytes and precursor cells predicts clinical outcomes of Parkinson’s diseaseSemantic proximity Read

Motor System Oligodendroglia Atlas Reveals Activation States Associated with Region-Specific Vulnerability in ALSSemantic proximity Read

Integrated Analysis of Single-Cell RNA Sequencing and Transcriptome Data Identifies a Pyroptosis-Associated Diagnostic Model for Parkinson’s DiseaseSemantic proximity Read

Motor System Oligodendroglia Atlas Reveals Activation States Associated with Region-Specific Vulnerability in ALSSemantic proximity Read

Single cell transcriptomics of human PINK1 iPSC differentiation dynamics reveal a core network of Parkinson’s diseaseSemantic proximity Read

Defining specific cell states of MPTP-induced Parkinson’s disease by single-nucleus RNA sequencingSemantic proximity Read

Distinctive genomic signature of neural and intestinal organoids from familial Parkinson's disease patient-derived induced pluripotent stem cells.Semantic proximity Read