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Article

LRRK2 signaling in neurodegeneration: two decades of progress.

Essays in biochemistry - 22 Dec 2021

Iannotta Lucia, Greggio Elisa

Abstract excerpt

Leucine-rich repeat kinase 2 (LRRK2) is a complex GTPase/kinase orchestrating cytoskeletal dynamics and multiple steps of the endolysosomal pathway through interaction with a host of partners and phosphorylation of a subset of Rab GTPases. Mutations in LRRK2 cause late-onset Parkinson's disease (PD) and common variants in the locus containing LRRK2 have been associated with sporadic PD, progressive supranuclear...

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Identifiers

PMID: 34897411
DOI: 10.1042/EBC20210013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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