Article
LRRK2 signaling in neurodegeneration: two decades of progress.
Essays in biochemistry - 22 Dec 2021
Iannotta Lucia, Greggio Elisa
Abstract excerpt
Leucine-rich repeat kinase 2 (LRRK2) is a complex GTPase/kinase orchestrating cytoskeletal dynamics and multiple steps of the endolysosomal pathway through interaction with a host of partners and phosphorylation of a subset of Rab GTPases. Mutations in LRRK2 cause late-onset Parkinson's disease (PD) and common variants in the locus containing LRRK2 have been associated with sporadic PD, progressive supranuclear...
Topics
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Lysosomes
- Mutation
- Parkinson Disease
- Phosphorylation
- Signal Transduction