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Article

Recurrence of bipolar mania is associated with catechol-O-methyltransferase Val(108/158)Met polymorphism.

Journal of affective disorders - 1 Jul 2011

Benedetti Francesco, Dallaspezia Sara, Locatelli Clara, Radaelli Daniele, Poletti Sara, Lorenzi Cristina, Pirovano Adele, Colombo Cristina, Smeraldi Enrico

Abstract excerpt

BACKGROUND: Catechol-O-methyltransferase (COMT) inactivates catecholamines, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity and the interaction between cortical and subcortical dopaminergic neurotransmission. In patients affected by bipolar disorder rs4680 can influence antidepressant response and the propensity to develop psychotic symptoms, with the Met/Met genotype exerting a...

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Source

Identifiers

PMID: 21397335
DOI: 10.1016/j.jad.2011.02.022

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Recurrence of bipolar mania is associated with catechol-O-methyltransferase Val(108/158)Met polymorphism.PMID 21397335Read ↗

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The Catechol-O-methyltransferase Val(108/158)Met Genetic Polymorphism cannot be Recommended as a Biomarker for the Prediction of Venlafaxine Efficacy in Patients Treated in Psychiatric Settings.Semantic proximity Read ↗

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