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Article

Polymorphisms in melatonin synthesis pathways: possible influences on depression

9 Aug 2011

Abstract excerpt

BACKGROUND: It has been reported that rs4446909, a single nucleotide polymorphism (SNP) in the promoter of acetylserotonin methyltransferase (ASMT), influences the expression of the ASMT enzyme. The common G allele is associated with lower ASMT activity, and therefore, diminishes conversion of N-acetylserotonin to melatonin. The G allele was associated with recurrent depressive disorder in a Polish group. ASMT...

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PMID: 21827647
DOI: 10.1186/1740-3391-9-8

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