Serotonin 5-HT2A receptor gene variants influence antidepressant response to repeated total sleep deprivation in bipolar depression.

doi:10.1016/j.pnpbp.2008.08.017

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Article

Serotonin 5-HT2A receptor gene variants influence antidepressant response to repeated total sleep deprivation in bipolar depression.

Progress in neuro-psychopharmacology & biological psychiatry - 12 Dec 2008

Benedetti Francesco, Barbini Barbara, Bernasconi Alessandro, Fulgosi Mara Cigala, Colombo Cristina, Dallaspezia Sara, Gavinelli Chiara, Marino Elena, Pirovano Adele, Radaelli Daniele, Smeraldi Enrico

Abstract excerpt

5-HT2A receptor density in prefrontal cortex was associated with depression and suicide. 5-HT2A receptor gene polymorphism rs6313 was associated with 5-HT2A receptor binding potential, with the ability of individuals to use environmental support in order to prevent depression, and with sleep improvement after antidepressant treatment with mirtazapine. Studies on response to antidepressant drugs gave inconsistent...

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PMID: 18801406
DOI: 10.1016/j.pnpbp.2008.08.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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