Effect of catechol-O-methyltransferase Val(108/158)Met polymorphism on antidepressant efficacy of fluvoxamine.

doi:10.1016/j.eurpsy.2009.12.007

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Article

Effect of catechol-O-methyltransferase Val(108/158)Met polymorphism on antidepressant efficacy of fluvoxamine.

European psychiatry : the journal of the Association of European Psychiatrists - 1 Dec 2010

Benedetti F, Dallaspezia S, Colombo C, Lorenzi C, Pirovano A, Smeraldi E

Abstract excerpt

RATIONALE: The catechol-O-methyltransferase (COMT) enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences the enzyme activity. Recent clinical studies found a significant effect of rs4680 on antidepressant response to fluoxetine and paroxetine, but severa...

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PMID: 20619611
DOI: 10.1016/j.eurpsy.2009.12.007

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COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20619611-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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