Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder.

Journal of affective disorders - 1 Sept 2010

Benedetti Francesco, Dallaspezia Sara, Colombo Cristina, Lorenzi Cristina, Pirovano Adele, Smeraldi Enrico

Abstract excerpt

BACKGROUND: Catechol-O-methyltransferase (COMT) inactivates catecholamines, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity and the interaction between cortical and subcortical dopaminergic neurotransmission. Studies in healthy participants and in patients affected by schizophrenia suggested that rs4680 can influence the propensity to develop psychotic symptoms, with the Met...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Alleles
Share to Bipolar Disorder
Share to Catechol O-Methyltransferase
Share to Delusions
Share to Hallucinations
Share to Homozygote
Share to Italy
Share to Polymorphism, Genetic

Source

Identifiers

PMID: 20122740
DOI: 10.1016/j.jad.2010.01.005

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder.PMID 20122740Read ↗

Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment.Semantic proximity Read ↗

Catechol-O-methyltransferase and the clinical features of psychosis.Semantic proximity Read ↗

Recurrence of bipolar mania is associated with catechol-O-methyltransferase Val(108/158)Met polymorphism.Semantic proximity Read ↗

Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder.Semantic proximity Read ↗

The effects of catechol-O-methyltransferase single nucleotide polymorphisms on positive and negative symptoms of schizophrenia: A systematic review and meta-analysis.Semantic proximity Read ↗

Influence of the catechol-O-methyltransferase Val108/158Met polymorphism on the plasma concentration of catecholamine metabolites and on clinical features in type I bipolar disorder--a preliminary report.Semantic proximity Read ↗

Association of the COMT synonymous polymorphism Leu136Leu and missense variant Val158Met with mood disorders.Semantic proximity Read ↗

The Role of a Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-analysis on 32,816 Subjects.Semantic proximity Read ↗

Association between Val108/158 Met polymorphism of the COMT gene and schizophrenia.Semantic proximity Read ↗

Association between COMT Val158Met and psychiatric disorders: A comprehensive meta-analysis.Semantic proximity Read ↗

Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis.Semantic proximity Read ↗

Manic symptom severity correlates with COMT activity in the striatum: A post-mortem study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.