Article
Zebrafish ift57, ift88, and ift172 intraflagellar transport mutants disrupt cilia but do not affect hedgehog signaling.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jul 2009
Lunt Shannon C, Haynes Tony, Perkins Brian D
Abstract excerpt
Cilia formation requires intraflagellar transport (IFT) proteins. Recent studies indicate that mammalian Hedgehog (Hh) signaling requires cilia. It is unclear, however, if the requirement for cilia and IFT proteins in Hh signaling represents a general rule for all vertebrates. Here we examine zebrafish ift57, ift88, and ift172 mutants and morphants for defects in Hh signaling. Although ift57 and ift88 mutants and...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Animals, Genetically Modified
- Carrier Proteins
- Cilia
- Embryo, Nonmammalian
- Gene Expression Regulation, Developmental
- Gene Knockdown Techniques
- Hedgehog Proteins
- Mutant Proteins