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Article

Hedgehog signalling in the mouse requires intraflagellar transport proteins.

Nature - 6 Nov 2003

Huangfu Danwei, Liu Aimin, Rakeman Andrew S, Murcia Noel S, Niswander Lee, Anderson Kathryn V

Abstract excerpt

Intraflagellar transport (IFT) proteins were first identified as essential factors for the growth and maintenance of flagella in the single-celled alga Chlamydomonas reinhardtii. In a screen for embryonic patterning mutations induced by ethylnitrosourea, here we identify two mouse mutants, wimple (wim) and flexo (fxo), that lack ventral neural cell types and show other phenotypes characteristic of defects in...

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Source

Identifiers

PMID: 14603322
DOI: 10.1038/nature02061

Genes

IFT88

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hedgehog signalling in the mouse requires intraflagellar transport proteins.PMID 14603322Read ↗

Analysis of hedgehog signaling in mouse intraflagellar transport mutants.Semantic proximity Read ↗

Cilia and Hedgehog responsiveness in the mouse.Semantic proximity Read ↗

Generation of mice with a conditional allele for Ift172.Semantic proximity Read ↗

The primary cilium as a Hedgehog signal transduction machine.Semantic proximity Read ↗

Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4.Semantic proximity Read ↗

An Ift80 mouse model of short rib polydactyly syndromes shows defects in hedgehog signalling without loss or malformation of ciliaSemantic proximity Read ↗

Intraflagellar transport is essential for endochondral bone formation.Semantic proximity Read ↗

Zebrafish ift57, ift88, and ift172 intraflagellar transport mutants disrupt cilia but do not affect hedgehog signaling.Semantic proximity Read ↗

Cilia and Hedgehog signaling in the mouse embryo.Semantic proximity Read ↗

A tissue-specific role for intraflagellar transport genes during craniofacial developmentSemantic proximity Read ↗

Loss of dynein-2 intermediate chain Wdr34 results in defects in retrograde ciliary protein trafficking and Hedgehog signaling in the mouse.Semantic proximity Read ↗

A hypomorphic allele reveals an important role of inturned in mouse skeletal development.Semantic proximity Read ↗

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