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Article

The intraflagellar transport protein IFT57 is required for cilia maintenance and regulates IFT-particle-kinesin-II dissociation in vertebrate photoreceptors.

Journal of cell science - 1 Jun 2008

Krock Bryan L, Perkins Brian D

Abstract excerpt

Defects in protein transport within vertebrate photoreceptors can result in photoreceptor degeneration. In developing and mature photoreceptors, proteins targeted to the outer segment are transported through the connecting cilium via the process of intraflagellar transport (IFT). In studies of vertebrate IFT, mutations in any component of the IFT particle typically abolish ciliogenesis, suggesting that IFT...

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Share to Cilia
Share to Kinesins
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18492793
DOI: 10.1242/jcs.029397
PMCID: PMC2637114

Genes

IFT57
IFT20
IFT88

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The intraflagellar transport protein IFT57 is required for cilia maintenance and regulates IFT-particle-kinesin-II dissociation in vertebrate photoreceptors.PMID 18492793Read ↗

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Unexpected Roles for Ciliary Kinesins and Intraflagellar Transport Proteins.Semantic proximity Read ↗

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IFT57 stabilizes the assembled intraflagellar transport complex and mediates transport of motility-related flagellar cargo.Semantic proximity Read ↗

Ciliary protein trafficking mediated by IFT and BBSome complexes with the aid of kinesin-2 and dynein-2 motorsSemantic proximity Read ↗

IFT20 is required for opsin trafficking and photoreceptor outer segment developmentSemantic proximity Read ↗

Elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8.Semantic proximity Read ↗

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Architecture of the IFT ciliary trafficking machinery and interplay between its componentsSemantic proximity Read ↗

Intraflagellar transport: from molecular characterisation to mechanismSemantic proximity Read ↗

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