Article
Analysis of hedgehog signaling in mouse intraflagellar transport mutants.
Methods in cell biology - 1 Jan 2009
Ko Hyuk W, Liu Aimin, Eggenschwiler Jonathan T
Abstract excerpt
Intraflagellar transport (IFT) has been studied for decades in model systems such as Chlamydomonas and Caenorhabditis elegans. More recently, IFT has been investigated using genetic approaches in mammals using the mouse as a model system. Through such studies, a new appreciation of the importance of IFT and cilia in mammalian signal transduction has emerged. Specifically, IFT has been shown to play a key role in...
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