Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Histone H4 lysine 16 acetylation regulates cellular lifespan.

Nature - 11 Jun 2009

Dang Weiwei, Steffen Kristan K, Perry Rocco, Dorsey Jean A, Johnson F Brad, Shilatifard Ali, Kaeberlein Matt, Kennedy Brian K, Berger Shelley L

Abstract excerpt

Cells undergoing developmental processes are characterized by persistent non-genetic alterations in chromatin, termed epigenetic changes, represented by distinct patterns of DNA methylation and histone post-translational modifications. Sirtuins, a group of conserved NAD(+)-dependent deacetylases or ADP-ribosyltransferases, promote longevity in diverse organisms; however, their molecular mechanisms in ageing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Acetyltransferases
Share to Histone Acetyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Deacetylase Inhibitors

Share to Histone Deacetylases

Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

Share to Sirtuin 2

Share to Sirtuins

Source

Open in PubMed Open full text

Identifiers

PMID: 19516333
DOI: 10.1038/nature08085
PMCID: PMC2702157

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histone H4 lysine 16 acetylation regulates cellular lifespan.PMID 19516333Read ↗

HST1 increases replicative lifespan of a sir2Δ mutant in the absence of PDE2 in Saccharomyces cerevisiae.Semantic proximity Read ↗

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.Semantic proximity Read ↗

Sirtuins in yeast: phenotypes and tools.Semantic proximity Read ↗

SIRT6 in DNA repair, metabolism and ageing.Semantic proximity Read ↗

Sirtuins, Bioageing, and CancerSemantic proximity Read ↗

The Sir2 Family of Protein DeacetylasesSemantic proximity Read ↗

The conserved role of sirtuins in chromatin regulationSemantic proximity Read ↗

Chromosomal gradient of histone acetylation established by Sas2p and Sir2p functions as a shield against gene silencing.Semantic proximity Read ↗

The epigenetic regulator SIRT7 guards against mammalian cellular senescence induced by ribosomal DNA instabilitySemantic proximity Read ↗

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.Semantic proximity Read ↗

Inactivation of the Sas2 histone acetyltransferase delays senescence driven by telomere dysfunction.Semantic proximity Read ↗

SIRT6 in Senescence and Aging-Related Cardiovascular DiseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.