Article
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.
Nature - 27 Mar 2008
Michishita Eriko, McCord Ronald A, Berber Elisabeth, Kioi Mitomu, Padilla-Nash Hesed, Damian Mara, Cheung Peggie, Kusumoto Rika, Kawahara Tiara L A, Barrett J Carl, Chang Howard Y, Bohr Vilhelm A, Ried Thomas, Gozani Or, Chua Katrin F
Abstract excerpt
The Sir2 deacetylase regulates chromatin silencing and lifespan in Saccharomyces cerevisiae. In mice, deficiency for the Sir2 family member SIRT6 leads to a shortened lifespan and a premature ageing-like phenotype. However, the molecular mechanisms of SIRT6 function are unclear. SIRT6 is a chromatin-associated protein, but no enzymatic activity of SIRT6 at chromatin has yet been detected, and the identity of...
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