HST1 increases replicative lifespan of a sir2Δ mutant in the absence of PDE2 in Saccharomyces cerevisiae.

doi:10.1007/s12275-017-6535-z

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Article

HST1 increases replicative lifespan of a sir2Δ mutant in the absence of PDE2 in Saccharomyces cerevisiae.

Journal of microbiology (Seoul, Korea) - 1 Feb 2017

Kang Woo Kyu, Devare Mayur, Kim Jeong-Yoon

Abstract excerpt

Silent information regulator 2 (Sir2), which is the founding member of the sirtuin family of proteins, is a pro-longevity factor for replicative lifespan (RLS) in Saccharomyces cerevisiae. Sir2 is required for transcriptional silencing at mating type loci, telomeres, and rDNA loci. Sir2 also represses transcription of highly expressed growth-related genes, such as PMA1 and some ribosomal protein genes. Although...

Topics

DNA Replication
DNA, Ribosomal
Mutation
Protein Binding
Proton-Translocating ATPases
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Silent Information Regulator Proteins, Saccharomyces cerevisiae
Sirtuin 2
Sodium Chloride

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PMID: 28120189
DOI: 10.1007/s12275-017-6535-z

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