Article
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.
Cell - 27 Jan 2006
Mostoslavsky Raul, Chua Katrin F, Lombard David B, Pang Wendy W, Fischer Miriam R, Gellon Lionel, Liu Pingfang, Mostoslavsky Gustavo, Franco Sonia, Murphy Michael M, Mills Kevin D, Patel Parin, Hsu Joyce T, Hong Andrew L, Ford Ethan, Cheng Hwei-Ling, Kennedy Caitlin, Nunez Nomeli, Bronson Roderick, Frendewey David, Auerbach Wojtek, Valenzuela David, Karow Margaret, Hottiger Michael O, Hursting Stephen, Barrett J Carl, Guarente Leonard, Mulligan Richard, Demple Bruce, Yancopoulos George D, Alt Frederick W
Abstract excerpt
The Sir2 histone deacetylase functions as a chromatin silencer to regulate recombination, genomic stability, and aging in budding yeast. Seven mammalian Sir2 homologs have been identified (SIRT1-SIRT7), and it has been speculated that some may have similar functions to Sir2. Here, we demonstrate that SIRT6 is a nuclear, chromatin-associated protein that promotes resistance to DNA damage and suppresses genomic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.