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SIRT6 in Senescence and Aging-Related Cardiovascular Diseases

29 Mar 2021

Abstract excerpt

SIRT6 belongs to the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases and has established diverse roles in aging, metabolism and disease. Its function is similar to the Silent Information Regulator 2 (SIR2), which prolongs lifespan and regulates genomic stability, telomere integrity, transcription, and DNA repair. It has been demonstrated that increasing the sirtuin level through genetic...

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PMID: 33855020
DOI: 10.3389/fcell.2021.641315

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