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Article

Chromosomal gradient of histone acetylation established by Sas2p and Sir2p functions as a shield against gene silencing.

Nature genetics - 1 Nov 2002

Kimura Akatsuki, Umehara Takashi, Horikoshi Masami

Abstract excerpt

Genes located in chromosomal regions near telomeres are transcriptionally silent, whereas those located in regions away from telomeres are not. Here we show that there is a gradient of acetylation of histone H4 at lysine 16 (H4-Lys16) along a yeast chromosome; this gradient ranges from a hypoacetylated state in regions near the telomere to a hyperacetylated state in more distant regions. The hyperacetylation is...

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Source

Identifiers

PMID: 12410229
DOI: 10.1038/ng993

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Chromosomal gradient of histone acetylation established by Sas2p and Sir2p functions as a shield against gene silencing.PMID 12410229Read ↗

Sir2p and Sas2p opposingly regulate acetylation of yeast histone H4 lysine16 and spreading of heterochromatin.Semantic proximity Read ↗

The silencing complex SAS-I links histone acetylation to the assembly of repressed chromatin by CAF-I and Asf1 in Saccharomyces cerevisiae.Semantic proximity Read ↗

Sir2 deacetylates histone H3 lysine 56 to regulate telomeric heterochromatin structure in yeast.Semantic proximity Read ↗

Inactivation of the Sas2 histone acetyltransferase delays senescence driven by telomere dysfunction.Semantic proximity Read ↗

Histone H4 lysine 16 acetylation regulates cellular lifespan.Semantic proximity Read ↗

Schizosaccharomyces pombe mst2+ encodes a MYST family histone acetyltransferase that negatively regulates telomere silencing.Semantic proximity Read ↗

Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases.Semantic proximity Read ↗

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.Semantic proximity Read ↗

Distinct roles for the essential MYST family HAT Esa1p in transcriptional silencing.Semantic proximity Read ↗

Histone H3 lysine 14 acetylation is required for activation of a DNA damage checkpoint in fission yeast.Semantic proximity Read ↗

The specificity of H2A.Z occupancy in the yeast genome and its relationship to transcription.Semantic proximity Read ↗

HST1 increases replicative lifespan of a sir2Δ mutant in the absence of PDE2 in Saccharomyces cerevisiae.Semantic proximity Read ↗

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