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Article

Inactivation of the Sas2 histone acetyltransferase delays senescence driven by telomere dysfunction.

The EMBO journal - 6 Jan 2010

Kozak Marina L, Chavez Alejandro, Dang Weiwei, Berger Shelley L, Ashok Annie, Guo Xiaoge, Johnson F Brad

Abstract excerpt

Changes in telomere chromatin have been linked to cellular senescence, but the underlying mechanisms and impact on lifespan are unclear. We found that inactivation of the Sas2 histone acetyltransferase delays senescence in Saccharomyces cerevisiae telomerase (tlc1) mutants through a homologous recombination-dependent mechanism. Sas2 acetylates histone H4 lysine 16 (H4K16), and telomere shortening in tlc1 mutants...

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Share to Acetylation
Share to Epistasis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Acetyltransferases

Share to Multiprotein Complexes

Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

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Source

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Identifiers

PMID: 19875981
DOI: 10.1038/emboj.2009.314
PMCID: PMC2808364

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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