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Article

The conserved role of sirtuins in chromatin regulation

1 Jan 2009

Abstract excerpt

The members of the Sir2 family, or Sirtuins, have garnered considerable attention because of their key roles as metabolic sensors and mediators of cell survival under stress. Sirtuins may play roles in myriad human pathologies such as cancer, neurological diseases, malaria, leishmaniasis and hormone-related disorders. They are present from prokaryotes to humans and show a high degree of functional diversification...

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PMID: 19378253
DOI: 10.1387/ijdb.082675av

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