High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients

Abstract excerpt

Transforming mutations in NRAS and KRAS are thought to play a causative role in the development of numerous cancers, including myeloid malignancies. Although mutations at amino acids 12, 13, or 61 account for the majority of oncogenic Ras variants, we hypothesized that less frequent mutations at alternate residues may account for disease in some patients with cancer of unexplained genetic etiology. To search for...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Acute Myeloid Leukemia Research
• Share to Protein Kinase Regulation and GTPase Signaling
• Share to Protein Tyrosine Phosphatases