Article
Setting the pace of the Neurospora circadian clock by multiple independent FRQ phosphorylation events.
Proceedings of the National Academy of Sciences of the United States of America - 30 Jun 2009
Tang Chi-Tai, Li Shaojie, Long Chengzu, Cha Joonseok, Huang Guocun, Li Lily, Chen She, Liu Yi
Abstract excerpt
Protein phosphorylation plays essential roles in eukaryotic circadian clocks. Like PERIOD in animals, the Neurospora core circadian protein FRQ is progressively phosphorylated and becomes extensively phosphorylated before its degradation. In this study, by using purified FRQ protein from Neurospora, we identified 43 in vivo FRQ phosphorylation sites by mass spectrometry analysis. In addition, we show that CK-1a...
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