Article
Functional analysis of the rodent CK1tau mutation in the circadian clock of a marine unicellular alga.
BMC cell biology - 15 Oct 2013
van Ooijen Gerben, Martin Sarah F, Barrios-Llerena Martin E, Hindle Matthew, Le Bihan Thierry, O'Neill John S, Millar Andrew J
Abstract excerpt
BACKGROUND: Casein Kinase 1 (CK1) is one of few proteins known to affect cellular timekeeping across metazoans, and the naturally occurring CK1tau mutation shortens circadian period in mammals. Functional conservation of a timekeeping function for CK1 in the green lineage was recently identified...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Casein Kinase I
- Chlorophyta
- Circadian Clocks
- Computational Biology
- Conserved Sequence
- Cricetinae
- Gene Expression
- Gene Expression Regulation, Plant
- Indoles
- Mice
- Molecular Sequence Data
- Mutation
- Phloroglucinol
- Phosphoproteins
- Phosphorylation