Article
Functional analysis of the rodent CK1tau mutation in the circadian clock of a marine unicellular alga.
BMC cell biology - 15 Oct 2013
van Ooijen Gerben, Martin Sarah F, Barrios-Llerena Martin E, Hindle Matthew, Le Bihan Thierry, O'Neill John S, Millar Andrew J
Abstract excerpt
BACKGROUND: Casein Kinase 1 (CK1) is one of few proteins known to affect cellular timekeeping across metazoans, and the naturally occurring CK1tau mutation shortens circadian period in mammals. Functional conservation of a timekeeping function for CK1 in the green lineage was recently identified in the green marine unicell Ostreococcus tauri, in spite of the absence of CK1's transcriptional targets known from...
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