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Article

Functional significance of FRH in regulating the phosphorylation and stability of Neurospora circadian clock protein FRQ.

The Journal of biological chemistry - 9 Apr 2010

Guo Jinhu, Cheng Ping, Liu Yi

Abstract excerpt

FREQUENCY (FRQ) is the central component of the Neurospora circadian clock. All FRQ proteins form the FFC complex with FRH (FRQ-interacting RNA helicase) that acts as the negative element in the circadian negative feedback loop by repressing frq mRNA levels. To understand the function of the FRQ-...

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Identifiers

PMID: 20159972
DOI: 10.1074/jbc.M109.071688
PMCID: PMC2857029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20159972-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Functional significance of FRH in regulating the phosphorylation and stability of Neurospora circadian clock protein FRQ.PMID 20159972Read ↗

FRQ-interacting RNA helicase mediates negative and positive feedback in the Neurospora circadian clock.Semantic proximity Read ↗

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Conserved RNA helicase FRH acts nonenzymatically to support the intrinsically disordered neurospora clock protein FRQ.Semantic proximity Read ↗

Phosphorylation of the Neurospora clock protein FREQUENCY determines its degradation rate and strongly influences the period length of the circadian clock.Semantic proximity Read ↗

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CKI and CKII mediate the FREQUENCY-dependent phosphorylation of the WHITE COLLAR complex to close the Neurospora circadian negative feedback loop.Semantic proximity Read ↗

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Long and short isoforms of Neurospora clock protein FRQ support temperature-compensated circadian rhythms.Semantic proximity Read ↗

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