Article
Phosphorylation of FREQUENCY protein by casein kinase II is necessary for the function of the Neurospora circadian clock.
Molecular and cellular biology - 1 Sept 2003
Yang Yuhong, Cheng Ping, He Qiyang, Wang Lixin, Liu Yi
Abstract excerpt
FREQUENCY (FRQ), a key component of the Neurospora circadian clock, is progressively phosphorylated after its synthesis. Previously, we identified casein kinase II (CKII) as a kinase that phosphorylates FRQ. Disruption of the catalytic subunit of CKII abolishes the clock function; it also causes severe defects in growth and development. To further establish the role of CKII in clock function, one of the CKII...
Topics
- Biological Clocks
- Casein Kinase II
- Casein Kinases
- Cell Nucleus
- Circadian Rhythm
- Cytoplasm
- Darkness
- Fungal Proteins
- Mutation
- Neurospora
- Phosphorylation