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Article

CKI and CKII mediate the FREQUENCY-dependent phosphorylation of the WHITE COLLAR complex to close the Neurospora circadian negative feedback loop.

Genes & development - 15 Sept 2006

He Qun, Cha Joonseok, He Qiyang, Lee Heng-Chi, Yang Yuhong, Liu Yi

Abstract excerpt

The eukaryotic circadian oscillators consist of circadian negative feedback loops. In Neurospora, it was proposed that the FREQUENCY (FRQ) protein promotes the phosphorylation of the WHITE COLLAR (WC) complex, thus inhibiting its activity. The kinase(s) involved in this process is not known. In this study, we show that the disruption of the interaction between FRQ and CK-1a (a casein kinase I homolog) results in...

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Identifiers

PMID: 16980584
DOI: 10.1101/gad.1463506
PMCID: PMC1578678

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Source receipt: pubmed, retrieved 7 Sept 2026.

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CKI and CKII mediate the FREQUENCY-dependent phosphorylation of the WHITE COLLAR complex to close the Neurospora circadian negative feedback loop.PMID 16980584Read ↗

Phosphorylation of FREQUENCY protein by casein kinase II is necessary for the function of the Neurospora circadian clock.Semantic proximity Read ↗

Light-independent phosphorylation of WHITE COLLAR-1 regulates its function in the Neurospora circadian negative feedback loop.Semantic proximity Read ↗

The genetics of circadian rhythms in Neurospora.Semantic proximity Read ↗

FRQ-CK1 Interaction Underlies Temperature Compensation of the Neurospora Circadian Clock.Semantic proximity Read ↗

Domains required for the interaction of the central negative element FRQ with its transcriptional activator WCC within the core circadian clock of Neurospora.Semantic proximity Read ↗

FRQ-interacting RNA helicase mediates negative and positive feedback in the Neurospora circadian clock.Semantic proximity Read ↗

Transcriptional repression of frequency by the IEC-1-INO80 complex is required for normal Neurospora circadian clock function.Semantic proximity Read ↗

Execution of the circadian negative feedback loop in Neurospora requires the ATP-dependent chromatin-remodeling enzyme CLOCKSWITCH.Semantic proximity Read ↗

PAS domain-mediated WC-1/WC-2 interaction is essential for maintaining the steady-state level of WC-1 and the function of both proteins in circadian clock and light responses of Neurospora.Semantic proximity Read ↗

Phosphorylation of the Neurospora clock protein FREQUENCY determines its degradation rate and strongly influences the period length of the circadian clock.Semantic proximity Read ↗

Setting the pace of the Neurospora circadian clock by multiple independent FRQ phosphorylation events.Semantic proximity Read ↗

Neurospora WC-1 recruits SWI/SNF to remodel frequency and initiate a circadian cycle.Semantic proximity Read ↗

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