Article
Distinct roles for PP1 and PP2A in the Neurospora circadian clock.
Genes & development - 1 Feb 2004
Yang Yuhong, He Qun, Cheng Ping, Wrage Philip, Yarden Oded, Liu Yi
Abstract excerpt
Phosphorylation of the Neurospora circadian clock protein FREQUENCY by several kinases promotes its degradation and is important for the function of the circadian feedback loop. Here, we show that FRQ is less stable in a ppp-1 (catalytic subunit of PP1) mutant, resulting in its advanced phase and short period. In contrast, FRQ stability is not altered in a rgb-1 (a regulatory subunit of PP2A) mutant, but levels...
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