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Article

Phosphorylation of the Neurospora clock protein FREQUENCY determines its degradation rate and strongly influences the period length of the circadian clock.

Proceedings of the National Academy of Sciences of the United States of America - 4 Jan 2000

Liu Y, Loros J, Dunlap J C

Abstract excerpt

Under free running conditions, FREQUENCY (FRQ) protein, a central component of the Neurospora circadian clock, is progressively phosphorylated, becoming highly phosphorylated before its degradation late in the circadian day. To understand the biological function of FRQ phosphorylation, kinase inhibitors were used to block FRQ phosphorylation in vivo and the effects on FRQ and the clock observed....

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Identifiers

PMID: 10618401
DOI: 10.1073/pnas.97.1.234
PMCID: PMC26646

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Phosphorylation of the Neurospora clock protein FREQUENCY determines its degradation rate and strongly influences the period length of the circadian clock.PMID 10618401Read ↗

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