Article
Circadian rhythms. Decoupling circadian clock protein turnover from circadian period determination.
Science (New York, N.Y.) - 30 Jan 2015
Larrondo Luis F, Olivares-Yañez Consuelo, Baker Christopher L, Loros Jennifer J, Dunlap Jay C
Abstract excerpt
The mechanistic basis of eukaryotic circadian oscillators in model systems as diverse as Neurospora, Drosophila, and mammalian cells is thought to be a transcription-and-translation-based negative feedback loop, wherein progressive and controlled phosphorylation of one or more negative elements ultimately elicits their own proteasome-mediated degradation, thereby releasing negative feedback and determining...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.