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Article

SMC5 and MMS21 are required for chromosome cohesion and mitotic progression.

Cell cycle (Georgetown, Tex.) - 15 Jul 2009

Behlke-Steinert Susanne, Touat-Todeschini Leila, Skoufias Dimitrios A, Margolis Robert L

Abstract excerpt

Members of the structural maintenance of chromosome (SMC) protein family have essential functions during mitosis, ensuring chromosome condensation (SMC2/4) and cohesion (SMC1/3). The SMC5/6 complex has been implicated in a variety of DNA maintenance processes but unlike the other SMC proteins, SM...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19502785
DOI: 10.4161/cc.8.14.8979

Genes

SMC5
SMC6
SMC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19502785-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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SMC5 and MMS21 are required for chromosome cohesion and mitotic progression.PMID 19502785Read ↗

The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages.Semantic proximity Read ↗

Conditional mutation of Smc5 in mouse embryonic stem cells perturbs condensin localization and mitotic progression.Semantic proximity Read ↗

Smc5/6 is required for repair at collapsed replication forks.Semantic proximity Read ↗

Pds5p regulates the maintenance of sister chromatid cohesion and is sumoylated to promote the dissolution of cohesion.Semantic proximity Read ↗

SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions.Semantic proximity Read ↗

SMC complexes and topoisomerase II work together so that sister chromatids can work apart.Semantic proximity Read ↗

H2A.Z-dependent regulation of cohesin dynamics on chromosome arms.Semantic proximity Read ↗

A role for Drosophila SMC4 in the resolution of sister chromatids in mitosis.Semantic proximity Read ↗

Smc5/6 maintains stalled replication forks in a recombination-competent conformation.Semantic proximity Read ↗

Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis.Semantic proximity Read ↗

SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes.Semantic proximity Read ↗

Smc5p promotes faithful chromosome transmission and DNA repair in Saccharomyces cerevisiae.Semantic proximity Read ↗

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