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Article

A role for Drosophila SMC4 in the resolution of sister chromatids in mitosis.

Current biology : CB - 6 Mar 2001

Steffensen S, Coelho P A, Cobbe N, Vass S, Costa M, Hassan B, Prokopenko S N, Bellen H, Heck M M, Sunkel C E

Abstract excerpt

BACKGROUND: Faithful segregation of the genome during mitosis requires interphase chromatin to be condensed into well-defined chromosomes. Chromosome condensation involves a multiprotein complex known as condensin that associates with chromatin early in prophase. Until now, genetic analysis of SMC subunits of the condensin complex in higher eukaryotic cells has not been performed, and consequently the detailed...

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Source

Identifiers

PMID: 11267866
DOI: 10.1016/s0960-9822(01)00096-3

Genes

SMC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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A role for Drosophila SMC4 in the resolution of sister chromatids in mitosis.PMID 11267866Read ↗

Mutations in the Drosophila condensin subunit dCAP-G: defining the role of condensin for chromosome condensation in mitosis and gene expression in interphase.Semantic proximity Read ↗

A role for condensin-mediator interaction in mitotic chromosome organization.Semantic proximity Read ↗

Conditional mutation of Smc5 in mouse embryonic stem cells perturbs condensin localization and mitotic progression.Semantic proximity Read ↗

SMC5 and MMS21 are required for chromosome cohesion and mitotic progression.Semantic proximity Read ↗

MCPH1 inhibits condensin II during interphase by regulating its SMC2-kleisin interfaceSemantic proximity Read ↗

Faithful anaphase is ensured by Mis4, a sister chromatid cohesion molecule required in S phase and not destroyed in G1 phase.Semantic proximity Read ↗

Pds5p is an essential chromosomal protein required for both sister chromatid cohesion and condensation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Condensin II is required for efficient Spindle Assembly Checkpoint activation in Drosophila male meiosisSemantic proximity Read ↗

SMC complexes and topoisomerase II work together so that sister chromatids can work apart.Semantic proximity Read ↗

Mutation of YCS4, a budding yeast condensin subunit, affects mitotic and nonmitotic chromosome behavior.Semantic proximity Read ↗

Coordination of DNA damage responses via the Smc5/Smc6 complex.Semantic proximity Read ↗

Condensin-dependent rDNA decatenation introduces a temporal pattern to chromosome segregation.Semantic proximity Read ↗

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