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Article

Conditional mutation of Smc5 in mouse embryonic stem cells perturbs condensin localization and mitotic progression.

Journal of cell science - 15 Apr 2016

Pryzhkova Marina V, Jordan Philip W

Abstract excerpt

Correct duplication of stem cell genetic material and its appropriate segregation into daughter cells are requisites for tissue, organ and organism homeostasis. Disruption of stem cell genomic integrity can lead to developmental abnormalities and cancer. Roles of the Smc5/6 structural maintenance of chromosomes complex in pluripotent stem cell genome maintenance have not been investigated, despite its important...

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Identifiers

PMID: 26919979
DOI: 10.1242/jcs.179036
PMCID: PMC4852767

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