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Article

SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes.

Development (Cambridge, England) - 1 May 2017

Hwang Grace, Sun Fengyun, O'Brien Marilyn, Eppig John J, Handel Mary Ann, Jordan Philip W

Abstract excerpt

SMC complexes include three major classes: cohesin, condensin and SMC5/6. However, the localization pattern and genetic requirements for the SMC5/6 complex during mammalian oogenesis have not previously been examined. In mouse oocytes, the SMC5/6 complex is enriched at the pericentromeric heterochromatin, and also localizes along chromosome arms during meiosis. The infertility phenotypes of females with a...

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Identifiers

PMID: 28302748
DOI: 10.1242/dev.145607
PMCID: PMC5450844

Genes

SMC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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