Article
Endogenous activation patterns of Cdc42 GTPase within Drosophila embryos.
Science (New York, N.Y.) - 5 Jun 2009
Kamiyama Daichi, Chiba Akira
Abstract excerpt
Knowing when and where a given protein is activated within intact animals assists in elucidating its in vivo function. With the use of a genetically encoded A-probe (activation bioprobe), we revealed that Cdc42 guanosine triphosphatase (GTPase) remains inactive within Drosophila embryos during the first two-thirds of embryogenesis. Within the central nervous system where Cdc42 activity first becomes up-regulated,...
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