Article
Cdc42 regulates junctional actin but not cell polarization in the Caenorhabditis elegans epidermis.
The Journal of cell biology - 6 Nov 2017
Zilberman Yuliya, Abrams Joshua, Anderson Dorian C, Nance Jeremy
Abstract excerpt
During morphogenesis, adherens junctions (AJs) remodel to allow changes in cell shape and position while preserving adhesion. Here, we examine the function of Rho guanosine triphosphatase CDC-42 in AJ formation and regulation during Caenorhabditis elegans embryo elongation, a process driven by asymmetric epidermal cell shape changes. cdc-42 mutant embryos arrest during elongation with epidermal ruptures....
Topics
- Actins
- Adherens Junctions
- Animals
- Animals, Genetically Modified
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Cycle Proteins
- Cell Polarity
- Embryo, Nonmammalian
- Epidermis
- Epithelial Cells
- GTP-Binding Proteins
- GTPase-Activating Proteins