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Article

Spontaneous Cdc42 polarization independent of GDI-mediated extraction and actin-based trafficking.

PLoS biology - 1 Apr 2015

Bendezú Felipe O, Vincenzetti Vincent, Vavylonis Dimitrios, Wyss Romain, Vogel Horst, Martin Sophie G

Abstract excerpt

The small Rho-family GTPase Cdc42 is critical for cell polarization and polarizes spontaneously in absence of upstream spatial cues. Spontaneous polarization is thought to require dynamic Cdc42 recycling through Guanine nucleotide Dissociation Inhibitor (GDI)-mediated membrane extraction and vesicle trafficking. Here, we describe a functional fluorescent Cdc42 allele in fission yeast, which demonstrates Cdc42...

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Identifiers

PMID: 25837586
DOI: 10.1371/journal.pbio.1002097
PMCID: PMC4383620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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