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Article

CGEF-1 and CHIN-1 regulate CDC-42 activity during asymmetric division in the Caenorhabditis elegans embryo.

Molecular biology of the cell - 15 Jan 2010

Kumfer Kraig T, Cook Steven J, Squirrell Jayne M, Eliceiri Kevin W, Peel Nina, O'Connell Kevin F, White John G

Abstract excerpt

The anterior-posterior axis of the Caenorhabditis elegans embryo is elaborated at the one-cell stage by the polarization of the partitioning (PAR) proteins at the cell cortex. Polarization is established under the control of the Rho GTPase RHO-1 and is maintained by the Rho GTPase CDC-42. To unde...

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Share to Caenorhabditis elegans Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Nonmammalian

Share to GTPase-Activating Proteins

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Source

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Identifiers

PMID: 19923324
DOI: 10.1091/mbc.e09-01-0060
PMCID: PMC2808230

Genes

RHO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19923324-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

CGEF-1 and CHIN-1 regulate CDC-42 activity during asymmetric division in the Caenorhabditis elegans embryo.PMID 19923324Read ↗

Functions of the novel RhoGAP proteins RGA-3 and RGA-4 in the germ line and in the early embryo of C. elegans.Semantic proximity Read ↗

PAR-2, LGL-1 and the CDC-42 GAP CHIN-1 act in distinct pathways to maintain polarity in the C. elegans embryo.Semantic proximity Read ↗

RhoA activation during polarization and cytokinesis of the early <i>Caenorhabditis elegans</i> embryo is differentially dependent on NOP-1 and CYK-4Semantic proximity Read ↗

CDC-42 controls early cell polarity and spindle orientation in C. elegans.Semantic proximity Read ↗

CDC-42 regulates PAR protein localization and function to control cellular and embryonic polarity in C. elegans.Semantic proximity Read ↗

Rho-binding kinase (LET-502) and myosin phosphatase (MEL-11) regulate cytokinesis in the early Caenorhabditis elegans embryo.Semantic proximity Read ↗

Cdc42 regulates junctional actin but not cell polarization in the Caenorhabditis elegans epidermis.Semantic proximity Read ↗

Cortical forces and CDC-42 control clustering of PAR proteins for Caenorhabditis elegans embryonic polarization.Semantic proximity Read ↗

The Rho guanine exchange factor RHGF-2 acts through the Rho-binding kinase LET-502 to mediate embryonic elongation in C. elegans.Semantic proximity Read ↗

pix-1 controls early elongation in parallel with mel-11 and let-502 in Caenorhabditis elegans.Semantic proximity Read ↗

The C. elegans homolog of Drosophila Lethal giant larvae functions redundantly with PAR-2 to maintain polarity in the early embryo.Semantic proximity Read ↗

Cell Polarity Regulates Biased Myosin Activity and Dynamics during Asymmetric Cell Division via Drosophila Rho Kinase and Protein Kinase N.Semantic proximity Read ↗

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