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Article

Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC.

Journal of cell science - 15 Sept 2007

Atwood Scott X, Chabu Chiswili, Penkert Rhiannon R, Doe Chris Q, Prehoda Kenneth E

Abstract excerpt

Cdc42 recruits Par-6-aPKC to establish cell polarity from worms to mammals. Although Cdc42 is reported to have no function in Drosophila neuroblasts, a model for cell polarity and asymmetric cell division, we show that Cdc42 colocalizes with Par-6-aPKC at the apical cortex in a Bazooka-dependent manner, and is required for Par-6-aPKC localization. Loss of Cdc42 disrupts neuroblast polarity: cdc42 mutant...

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Identifiers

PMID: 17726059
DOI: 10.1242/jcs.014902
PMCID: PMC1988841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC.PMID 17726059Read ↗

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