Article
Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC.
Journal of cell science - 15 Sept 2007
Atwood Scott X, Chabu Chiswili, Penkert Rhiannon R, Doe Chris Q, Prehoda Kenneth E
Abstract excerpt
Cdc42 recruits Par-6-aPKC to establish cell polarity from worms to mammals. Although Cdc42 is reported to have no function in Drosophila neuroblasts, a model for cell polarity and asymmetric cell division, we show that Cdc42 colocalizes with Par-6-aPKC at the apical cortex in a Bazooka-dependent manner, and is required for Par-6-aPKC localization. Loss of Cdc42 disrupts neuroblast polarity: cdc42 mutant...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Cell Division
- Cell Polarity
- Central Nervous System
- Drosophila Proteins
- Drosophila melanogaster
- GTP-Binding Proteins
- Genes, Dominant
- Intracellular Signaling Peptides and Proteins
- Mice
- Mice, Knockout
- Mutation