Article
Genotypic analysis of genes associated with isoniazid and ethionamide resistance in MDR-TB isolates from Thailand.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Apr 2010
Boonaiam S, Chaiprasert A, Prammananan T, Leechawengwongs M
Abstract excerpt
Nucleotide sequences of genes conferring isoniazid resistance (katG, inhA, oxyR-ahpC and ndh) and ethionamide resistance (ethA) in 160 drug-resistant Mycobacterium tuberculosis clinical isolates from Thailand were analysed. Mutations in the katG gene were found in 129 isolates, predominantly at codon 315, which was mutated in 127 isolates. Twenty-two isolates had mutations in the inhA promoter and coding region....
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