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Article

Spoligotype-based population structure and isoniazid-resistance gene mutation of Mycobacterium tuberculosis isolates from Thailand.

Journal of global antimicrobial resistance - 1 Sept 2022

Krittanan Peerapat, Srimanote Potjanee, Thawornwan Unchana, Chaiprasert Angkana, Tapchaisri Pramaun, Tongtawe Pongsri

Abstract excerpt

OBJECTIVES: The present study aims to investigate the population structure of Thai Mycobacterium tuberculosis (MTB) isolates and anti-tuberculosis (TB) drug resistance and to determine the most frequent genetic mutations conferring isoniazid (INH) resistance. METHODS: Genomic DNA from 287 MTB clinical isolates were extracted and used for spoligotyping, amplification and sequencing analysis of the region of...

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PMID: 35732265
DOI: 10.1016/j.jgar.2022.06.013

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