Article
Molecular characterization of isoniazid-resistant Mycobacterium tuberculosis clinical strains isolated in the Philippines.
International journal of antimicrobial agents - 1 Jun 2004
Herrera Laura, Valverde Azucena, Saiz Pilar, Sáez-Nieto Juan A, Portero José L, Jiménez M Soledad
Abstract excerpt
The prevalence of mutations in the katG, inhA and oxyR-ahpC genes of isoniazid (INH)-resistant Mycobacterium tuberculosis isolates in the Philippines were determined. Of 306 M. tuberculosis isolates studied, 81 (26.5%) exhibited INH-resistance. Forty-four strains (54.3%) had mutations in the katG gene, eighteen strains (22.2%) had mutations in the putative inhA locus region, seven had mutations in both regions...
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