Article
Screening and characterization of mutations in isoniazid-resistant Mycobacterium tuberculosis isolates obtained in Brazil.
Antimicrobial agents and chemotherapy - 1 Sept 2004
Cardoso Rosilene Fressatti, Cooksey Robert C, Morlock Glenn P, Barco Patricia, Cecon Leticia, Forestiero Francisco, Leite Clarice Q F, Sato Daisy N, Shikama Maria de Lourdes, Mamizuka Elsa M, Hirata Rosario D C, Hirata Mario H
Abstract excerpt
We investigated mutations in the genes katG, inhA (regulatory and structural regions), and kasA and the oxyR-ahpC intergenic region of 97 isoniazid (INH)-resistant and 60 INH-susceptible Mycobacterium tuberculosis isolates obtained in two states in Brazil: São Paulo and Paraná. PCR-single-strand conformational polymorphism (PCR-SSCP) was evaluated for screening mutations in regions of prevalence, including codons...
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