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Article

DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2009

Nosho Katsuhiko, Shima Kaori, Irahara Natsumi, Kure Shoko, Baba Yoshifumi, Kirkner Gregory J, Chen Li, Gokhale Sumita, Hazra Aditi, Spiegelman Donna, Giovannucci Edward L, Jaenisch Rudolf, Fuchs Charles S, Ogino Shuji

Abstract excerpt

PURPOSE: DNA methyltransferase-3B (DNMT3B) plays an important role in de novo CpG island methylation. Dnmt3b can induce colon tumor in mice with methylation in specific CpG islands. We hypothesized that cellular DNMT3B level might influence the occurrence of widespread CpG island methylation (i.e., the CpG island methylator phenotype, CIMP) in colon cancer. EXPERIMENTAL DESIGN: Utilizing 765 colorectal cancers in...

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Identifiers

PMID: 19470733
DOI: 10.1158/1078-0432.CCR-08-2383
PMCID: PMC2866637

Genes

BRAF
CHFR
CRABP1
HIC1
IGF2
IGFBP3
KRAS
MGMT
MLH1
NEUROG1
RUNX3
SOCS1
WRN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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