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Article

Gnao1 (G alphaO protein) is a likely genetic contributor to variation in physical dependence on opioids in mice.

Neuroscience - 15 Sept 2009

Kest B, Smith S B, Schorscher-Petcu A, Austin J-S, Ritchie J, Klein G, Rossi G C, Fortin A, Mogil J S

Abstract excerpt

Chronic exposure to opioids leads to physical dependence, which manifests as the symptoms of drug withdrawal. Interindividual differences in withdrawal symptom severity are well known, and at least partially due to genetic variation. To identify genes contributing to variation in withdrawal severity, we chronically treated 30 strains of the AcB/BcA recombinant congenic mouse strain set, including their A/J and...

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Share to Chromosomes, Mammalian
Share to Crosses, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to GTP-Binding Protein alpha Subunits, Gi-Go

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Share to Mice, Congenic

Share to Oligonucleotides, Antisense

Share to Substance Withdrawal Syndrome

Source

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PMID: 19460419
DOI: 10.1016/j.neuroscience.2009.05.027

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NPW

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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