Article
Genetic variation regulates opioid-induced respiratory depression in mice.
Scientific reports - 11 Sept 2020
Bubier Jason A, He Hao, Philip Vivek M, Roy Tyler, Hernandez Christian Monroy, Bernat Rebecca, Donohue Kevin D, O'Hara Bruce F, Chesler Elissa J
Abstract excerpt
In the U.S., opioid prescription for treatment of pain nearly quadrupled from 1999 to 2014. The diversion and misuse of prescription opioids along with increased use of drugs like heroin and fentanyl, has led to an epidemic in addiction and overdose deaths. The most common cause of opioid overdose and death is opioid-induced respiratory depression (OIRD), a life-threatening depression in respiratory rate thought...
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