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Article

Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.

Alcohol and alcoholism (Oxford, Oxfordshire). Supplement - 1 Jan 1994

Crabbe J C, Belknap J K, Buck K J, Metten P

Abstract excerpt

A recently-developed method of gene mapping is reviewed. Several responses to EtOH were studied with the purpose of identifying genes with modest effects (Quantitative Trait Loci, or QTLs). As an example, results from a study of acute ethanol withdrawal severity are discussed. Mice from inbred strains C57BL/6J and DBA/2J, and 19 of their Recombinant Inbred (BXD RI) strains, were given 4 g/kg EtOH and their acute...

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PMID: 8974318

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