Article
The α3β4* nicotinic ACh receptor subtype mediates physical dependence to morphine: mouse and human studies.
British journal of pharmacology - 1 Aug 2014
Muldoon P P, Jackson K J, Perez E, Harenza J L, Molas S, Rais B, Anwar H, Zaveri N T, Maldonado R, Maskos U, McIntosh J M, Dierssen M, Miles M F, Chen X, De Biasi M, Damaj M I
Abstract excerpt
BACKGROUND AND PURPOSE: Recent data have indicated that α3β4* neuronal nicotinic (n) ACh receptors may play a role in morphine dependence. Here we investigated if nACh receptors modulate morphine physical withdrawal. EXPERIMENTAL APPROACHES: To assess the role of α3β4* nACh receptors in morphine withdrawal, we used a genetic correlation approach using publically available datasets within the GeneNetwork web...
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