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Article

Association of the c.3972C>T variant of the multidrug resistance-associated protein 2 Gene (MRP2/ABCC2) with susceptibility to bile duct cancer.

Digestion - 1 Jan 2009

Hoblinger A, Grunhage F, Sauerbruch T, Lammert F

Abstract excerpt

BACKGROUND: Multidrug resistance-associated protein 2 (MRP2/ABCC2) is one of the ATP-binding cassette (ABC) transporters expressed on the apical membrane of hepatocytes and cholangiocytes. ABCC2 plays an important role in the biliary clearance of endogenous and exogenous toxic compounds. Recently, the ABCC2 variant c.3972C>T in exon 28 has been shown to be associated with hepatocellular carcinoma risk. Our aim...

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Source

Identifiers

PMID: 19451719
DOI: 10.1159/000212990

Genes

ABCC2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of the c.3972C>T variant of the multidrug resistance-associated protein 2 Gene (MRP2/ABCC2) with susceptibility to bile duct cancer.PMID 19451719Read ↗

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The association of transporter ABCC2 (MRP2) genetic variation and drug-induced hyperbilirubinemia.Semantic proximity Read ↗

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