Article
Genetic factors in the pathogenesis of cholangiocarcinoma.
Digestive diseases (Basel, Switzerland) - 1 Jan 2011
Wadsworth Christopher A, Dixon Peter H, Wong Jason H, Chapman Michael H, McKay Siobhan C, Sharif Amar, Spalding Duncan R, Pereira Stephen P, Thomas Howard C, Taylor-Robinson Simon D, Whittaker John, Williamson Catherine, Khan Shahid A
Abstract excerpt
BACKGROUND: Cholangiocarcinoma (CC) is increasing in incidence, but its pathogenesis remains poorly understood. Chronic inflammation of the bile duct and cholestasis are major risk factors, but most cases in the West are sporadic. Genetic polymorphisms in biliary transporter proteins have been implicated in benign biliary disease and, in the case of progressive familial cholestasis, have been associated with...
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